Researchers discuss the development and validation of a combined model comprising imaging, clinical, and cell-free deoxyribonucleic acid (DNA) methylation biomarkers for improved classification of pulmonary nodules and the earlier diagnosis of lung cancer.
Study
In the present study, researchers develop a combined model of clinical and imaging biomarkers (CIBM) that uses machine learning algorithms, as well as imaging and clinical features, to classify malignant and benign pulmonary nodules. When combined with a model called PulmoSeek, which is a cell-free DNA methylation model previously designed by the same team of scientists, the CIBM model can detect small-sized pulmonary nodules to ultimately classify lung cancer in the early stages.
Study participants were recruited through a masked, retrospective evaluation study for prospective sample collection from hospitals across 20 Chinese cities. Individuals included in the study were 18 years or older, with 5-30 millimeter (mm) pulmonary nodules that were solitary and non-calcified, as well as solid, part-solid, or pure ground-glass nodules.
A cohort of over 800 samples was used to train the machine-learning algorithm of the CIBM model to classify benign and malignant tumors. The CIBM model was then integrated with PulmoSeek to create a combined model called PulmoSeek Plus.
A decision curve analysis was applied to evaluate the clinical use of the model. Low and high cut-offs for high sensitivity and high specificity, respectively, were used to classify pulmonary nodules into low-, medium-, and high-risk groups. The examined primary outcome was the performance and diagnostic ability of the three models PulmoSeek, CIBM, and PulmoSeek Plus.
Results
The PulmoSeek Plus model has the potential to successfully diagnose pulmonary nodules as benign or malignant in the early stages. When combined with LDCT, PulmoSeek Plus could be a robust tool for the early clinical assessment and management of lung cancer. Moreover, the only requirements for the integrated model were non-invasively collected blood samples and CT images.
Combining CIBM with the PulmoSeek model increased the sensitivity of the classification of pulmonary nodules by 6% and negative predictive value by 24%. Furthermore, the performance of the model was robust across pulmonary nodules of different types, sizes, and stages.
The sensitivities of characterization for early-stage nodules, as well as those smaller than one centimeter in size were 0.98 and 0.99, respectively. For sub-solid nodules, which are difficult to characterize using LDCT results alone, the characterization sensitivity was 100%.
Conclusion
The integrated PulmoSeek Plus model incorporates imaging, clinical, and cell-free DNA methylation biomarkers, as well as a machine-learning algorithm, for the early detection and classification of pulmonary nodules.
The validation of this model using independent cohorts confirms the high sensitivity and robust performance of PulmoSeek Plus across a range of samples. When combined with LDCT, PulmoSeek Plus could facilitate the early detection of lung cancers, thus improving the prognosis for many lung cancer patients.
Source:
https://www.news-medical.net/news/20230815/Early-lung-cancer-detection-with-a-machine-learning-model-based-on-imaging-clinical-and-DNA-methylation-biomarkers.aspx