The Indian Prime Minister Narendra Modi addressed in his speech about the importance of local manufacturing and supply chains amid the COVID-19 crisis. Coining slogan “Vocal for Local”, he spoke about that it is the need of the hour for the nation to come together to encourage local businesses and products. He addressed about the importance of using products that are made in India and he asserted that the country have to boost its economy that can transform local businesses. He embarked about the khadi and village industries that have successfully transitioned from local to global and these can be case studies for all local industries and enterprises. In times such as this the best way is being completely self-reliant and calling for a new form of globalization. It is important to step up and do everything we can to help revive the Indian economy and work towards managing our businesses with the tools to tide through such circumstances. Helping reviving the Indian economy, we can help to create more jobs, transform business processes and strengthen efficiency. Multiple insecurities were show by the countries when the pandemic began and hence fears of profit driven businesses multiplied with manifold overnight. The ongoing COVID-19 pandemic has forced companies and businesses to rethink about their operational strategies and due to this reason businesses are using this opportunity to boost production and exports. The positive vibes for Vocal for Local can be seen during the Diwali festive season when the country appreciated and purchased local products like diya used in Diwali instead of Chinese products. This proved that the support of such large number of people in favour towards Vocal for Local slogan during this festival season showed that this initiative will strengthen the local market and economy of the country.
Coronavirus disease 2019 (COVID-19) is a contagion caused severe acute respiratory syndrome by coronavirus 2 (SARS-CoV-2). The disease has spread worldwide, resulting in an ongoing pandemic. Symptoms of COVID-19 are variable, but often include fever, cough, fatigue, breathing difficulties, and loss of smell and taste. The health authorities in Denmark said that they are suspending the use of AstraZeneca's Covid-19 vaccine is a precautionary measure for some time after some patients incurred blood clots after receiving the inoculation and individual died. Similarly Norway and Iceland have also suspended the usage of AstraZeneca's COVID-19 vaccine for some time. Denmark banned the vaccination days after the following reports of serious cases of blood clots among people vaccinated with AstraZeneca's Covid-19 vaccine. The studies suggest that it has not been determined, at the nonce, that there's a link between the vaccine and therefore the blood clots. This has lead to temporary suspension of vaccine rollout until further notice. It has been reported that COVID-19 disease is strongly associated with blood clotting and there have been hundreds if not many thousands of deaths caused by blood clotting as a result of COVID-19 disease. However till the suspension, which will be reviewed after two weeks, there would be slowdown Denmark's vaccination campaign. Specifically, the vaccine mass production has been stopped in Denmark and studies are ongoing on the some tests which are negative and after concluding results about the ongoing tests the medicine would be scheduled for vaccination. Till the suspension, which will be reviewed after two weeks, there would be slowdown Denmark's vaccination campaign. Note: The above mentioned content is subjected to change as per the sources.
Currently India is working on two vaccines Covishield and Covaxin to fight Covid-19 in the country. The mass vaccination is likely to begin over the next few days for the common man, but initially it is vaccinated on doctors, nurses and other medical staff for the initial rollout. The Indian Government has given its approval that both these drugs can be used commercially. Covishield vaccine has been developed by the scientists of Oxford University in collaboration with AstraZeneca Pvt. Ltd. In India, its trial was undertaken by the Serum Institute of India which is also manufacturing the Covishield vaccine for the mass vaccination drive. Covaxin vaccine is developed by Bharat Biotech together with the Indian Council for Medical Research (ICMR). The ICMR director General Dr. Balram Bhargava has given his approval and expects to have it ready by June 2021 for mass vaccination unless the government advances its launch through emergency use authorization. Covishield vaccine has been developed by using adenovirus which causes cold infections among chimpanzees. The genetic material matches with the spike protein of SARS-CoV-2 coronavirus. The weakened version of the adenovirus is used for manufacturing Covishield vaccine. Covaxin vaccine has been manufactured using dead coronavirus, which is known as inactivated vaccine. In inactivated state, the virus is not proficient enough to infect people or replicate on its own inside the body of a person. The miniature of the vaccine prepares the immunity system to acknowlege the particular virus and fights it if infection happens. The Covaxin efficacy rate is market at above 60% against the the efficiency of Covishield, whose efficiency is pegged at over 70%. Both Covishield and Covaxin are two-dose vaccines. But in a stimulating development that was considered as inadvertent error, the Covishield vaccine was found to point out over 90 per cent efficacy if one and a half doses are given to the recipient. The two miniatures of Covishield vaccine need to be spaced by six weeks. In the case of Covaxin, the interval between the 2 miniatures has not been yet prescribed by the Drug Controller General of India (DCGI) but its developer Bharat Biotech had earlier said the second miniature would be given after 14 days. Both Covishield and Covaxin vaccines are easy to store as they require to be kept at 20C-80C. Most vaccines commonly utilized in India are kept at this temperature range. This makes transport and native storage of both Covid-19 vaccines safe and straightforward for all parts of the country. Though currently the government is controlling the vaccination drive against Covid-19, and it's free. Different reports have cited different prices for both the vaccines. The Covishield vaccine is reported to cost the government around Rs 250 including GST, whereas the Covaxin is priced at Rs 295 including GST. Note: The above mentioned content is subjected to change as per sources.
Brain related interfaces are emerging technologies to revive perception and action following different degenerative diseases and traumatic incidents. Electrical stimulation helps retina to generate phosphenes to patients who learn over time to associate them with basic vision. Currently these devices are not supporting features such as: Face recognition, independent locomotion, and text reading. For retinal prostheses conductive electrode materials with a high double layer capacitance are expected to supply spatial resolution. Carbon related materials like graphene and graphene derivatives are currently studied for their electrical properties as biosensors and neural interfacing. As neural interfacing materials, graphene and its derivatives are useful as an electrode material that is handy for recording and stimulation. Graphene is a single-layered and a 2-D material that has high electron mobility. Graphene is kept under high temperatures on metallic substrates such as chemical vapor deposition reactors. The high transparency of CVD graphene has already been seen in acute cortical recordings with calcium imaging also in measuring electroretinograms in non-human primates. So, graphene should be further studied to know deeply how it can be used in electrodes for retinal prostheses or in any other device for recording and stimulation of the central nervous system and brain. Further studies would access developed graphene structures on persistant devices to match biocompatibility, safety and stimulation capabilities between classic materials and graphene-based electrodes.
ETC-159 is a novel small molecule drug that targets a spread of cancers including colorectal, ovarian and pancreatic cancers. Its role is of an inhibitor in Wnt signalling pathways which promote cancer growth by allowing immune cells to access and enter the tumor. ETC-159 is been developed by partnership between . ETC-159 inhibits an enzyme called porcupine, which prevents the secretion of Wnt proteins. ETC-159 is being tested in a clinical trial for use in cancers with overactive Wnt signalling, amongst other therapeutic indications during dose escalation in patients with advanced solid tumors; the utmost tolerated dose of ETC-159 is 30 mg every other day with dose-limiting toxicities and toxicity of concern of elevated serum b-CTX. ETC-159 with prophylactic denosumab is safe. ETC-159 has PD activity and increases immune infiltration. Currently ETC-159 dosing is ongoing at 24 mg. The signal used for DNA repair helps to stop mutations from developing in stem cells residing inside the intestinal epithelium, further are often utilized in normal Wnt signalling in somatic cell maintenance. Analysis of pre-clinical studies shows that the therapeutic doses of ETC-159 are well tolerated by the gut, without causing toxicity. This reflects that when a moment dose of ETC-159, given alongside PARP inhibitors, can prevent cancer resistance, while sparing intestinal stem cells, providing further options for treating cancers with hyperactive Wnt signalling. The findings improve our understanding of how Wnt signalling enhances DNA repair in stem cells and cancers, maintaining their genomic integrity. Interventions that block Wnt signalling could cause some cancers and that they are often more sensitive to radiation and other DNA damaging agents. REFERENCES 1. https://www.duke-nus.edu.sg/allnews/duke-nus-represented-at-launch-of-a-star-experimental-drug-development-centre
TRIDHA Scholars is a group which is working for the growth of the researchers, scholars and students by publishing their valuable research work. TRIDHA Scholars is one of the world’s largest publishers of large number of high quality peer-reviewed, fully open access journals in all the fields of life sciences, Biology and Technologies. Our journals are indexed in recognized indexing agencies, such as H-Index (3), Google Scholar, Research Gate, Crossref (Member), Scilit, Semantic Scholars. We are having very well disguised Editorial in Chief who continuously advises us regarding how to improve our journals. Our Editorial Board Members consists authors from various scientific communities from across the globe. Some well known Editor in Chiefs working with us are:
miRNAs role within mammalian reproduction, allows a comparative understanding of fertility and sterility in male and females. The miRNA-mediated regulation of mammalian reproduction highlights the importance of miRNAs including the biogenesis of germ cells, the functionality of reproductive organs, and overall the development of early embryos. miRNAs are active regulators of various biological and physiological processes including most of the events of mammalian reproduction. Understanding the biological functions of miRNAs within the context of mammalian reproduction, allows a far better and comparative understanding of fertility and sterility in male and feminine mammals. The miRNA-mediated regulation of mammalian reproduction and highlight the importance of miRNAs in several aspects of mammalian reproduction including the biogenesis of germ cells, the functionality of reproductive organs, and therefore the development of early embryos. For proper development and function of the female reproductive tract the regulation of the differentiated functions of the organs that structure the female reproductive tract is to well known for multiple levels including transcription, translation, and posttranslational modifications. (miRNA) mediated posttranscriptional gene regulation has emerged as a fundamental mechanism controlling normal tissue development and performance. miRNAs are expressed within the organs of the feminine reproductive tract where they function to manage cellular pathways necessary for correct function of those organs. Role of miRNAs within the event of the organs of the feminine reproductive tract highlighting recent studies that clearly demonstrate that mice with disrupted Dicer1 expression are sterile, fail to develop uterine glands, and have muted estrogen responsiveness. miR-26b is expressed in high levels in fallopian tube and in cervix but not within the ovary and is proposed to manage apoptosis. miR-26a expression is abundant in bovine thymus, lymph nodes, small intestines, and embryo. miR-26a suppresses tumor proliferation as well as also antagonizes apoptosis and facilitates carcinogenesis via the regulation of EZH2 and MTDH. Micro-RNA (miRNA)-mediated posttranscriptional gene regulation has emerged as a fundamental mechanism controlling normal tissue development and performance. miRNAs are essential during pre and post fertilization stages such as sex differentiation, germline initiation, gametogenesis, pre-implantation development and implantation of embryos but have very limited roles during the fertilization event. miRNAs has a direct involvement in X‐linked gene expression during the MSCI process of spermatogenesis and in the initiation of first embryonic cell division.
Food processing & nutritional science is a double blind peer-reviewed, online only journal for rapid dissemination of research in all areas of food processing and nutritional science. The Journal will consider submissions of high quality articles describing the results of fundamental and applied research related to all aspects of food processing and nutritional science, as well as interdisciplinary research that spans these two fields.
Journal of Heart is a new initiative from the TRIDHA Society of Heart & Cardiology (volunteer-led, not-for-profit medical society) [Society Page is Under Production]. Journal of Heart is an authoritative, international peer reviewed and open access journal that keeps focusing on cardiologists and their up to date research advances in cardiovascular and cerebrovascular disease.
Tridha Scholars Group is passionate about working with the global academic community to promote open scholarly research to the world. The published articles are made highly visible to the scientific community through a wide indexing policy & advertisement adopted by the online international journals.